This phenotype calculates values from the Preop Creatinine (Most Recent within 60 days) phenotype

All values expressed in ml/min/1.73m2

Obtain the most recent valid eGFR within 60 days of anesthesia start.

1. Valid >0 and <300
2. If data invalid ? Output = -998
3. If data is completely missing ? Output = -999

If data is valid ? Output = (numeric value in ml/min/1.73m2)

Reference values:

• >150 ml/min/1.73m^2

eGFR can be derived from creatinine values: first conversion from mcmol/l to mg/dl for centers using SI units instead of Conventional Units. Then use:

References:

• Frank H. Wians, Jr., PhD; Merck Manuel, professional version; Blood Tests: Normal Values; accessed 10-17-2016;  http://www.merckmanuals.com/professional/appendixes/normal-laboratory-values/blood-tests-normal-values#v8508814
• Farmacotherapeutisch compass 2016,  the Netherlands; published 10-01-2016; accessed 10-17-2016; https://www.farmacotherapeutischkompas.nl/bladeren-volgens-boek/inleidingen/inl-referentiewaarden-klinische-chemie
• FDA, investigations operations manual 2015, appendix C, Blood Serum Chesitry – Normal Values ; published 2015, accessed 10-17-2016;  http://www.fda.gov/downloads/ICECI/Inspections/IOM/UCM135835.pdf

Adults >= 18 years old:

CKD-EPI

eGFR = 142 × min (Scr /a, 1)^a × max(Scr /a, 1)^-1.200 × 0.9938Age × 1.01 [if female]

1. Scr is serum creatinine in mg/dL,
2. a is 0.7 for females and 0.9 for males,
3. a is -0.241 for females and -0.302 for males
4. min indicates the minimum of Scr /a or 1
5. max indicates the maximum of Scr /a or 1.

Requirements:

1. Age is mandatory
2. If no gender data available assume female         

Reference:

• Inker, L. A., Eneanya, N. D., Coresh, J., Tighiouart, H., Wang, D., Sang, Y., Crews, D. C., Doria, A., Estrella, M. M., Froissart, M., Grams, M. E., Greene, T., Grubb, A., Gudnason, V., Gutiérrez, O. M., Kalil, R., Karger, A. B., Mauer, M., Navis, G., … Levey, A. S. (2021). New creatinine- and cystatin C–based equations to estimate GFR without race. New England Journal of Medicine, 385(19), 1737–1749. https://doi.org/10.1056/nejmoa2102953

Pediatric Patients <18 years old:

Bedside Schwartz

eGFR = 0.413 * (height in cm) / (baseline creatinine)

1. Height is mandatory

Reference:

• Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL.; New equations to estimate GFR in children with CKD.J Am Soc Nephrol. 2009 Mar;20(3):629-37